Insights into IVF Vs. ICSI

By Serene Anne


The birth of Louise Brown, the world's pioneer "test-tube baby" on July 25, 1978 presented the idea of IVF to people around the globe. IVF (in vitro fertilization) is a fertility method which involves obtaining sperms and eggs from a man and woman and putting them together in a clinical environment. Usually up to three fertilized eggs (embryos) are placed into the woman's metra where implantation and development will occur just as in a normal gestation. The average success rate per IVF cycle is roughly 20%.

IVF may be used if the woman is infertile due to a hormonal imbalance, an inability to produce eggs, or damaged or blocked fallopian tubes. An infection or scarring within the uterus and the presence of a tumor may cause her attempts to get pregnant futile. Besides, the older a woman is, the less likely she will be able to conceive children naturally.

On the other hand, if a woman is unable to get pregnant it is not necessarily lowing to her infertility. According to the National Institutes of Health, USA low sperm count is the reason for 30% - 40% of infertile couple. The general reasons for male infertility include deficiencies in the amount of the sperm and problems with ejaculation. Male infertility is usually diagnosed by a semen analysis.

The man provides a semen sample for a lab to evaluate. The lab will measure the amount of semen and the number of sperm, and to evaluate sperm shape and movement.Intra-cytoplasmic sperm injection (ICSI) was introduced in 1992. It is a fertilization technique that can help a woman who does not get pregnant by in-vitro fertilization.

ICSI can be used to help man and woman who had unsuccessful fertilization after standard IVF procedures or could not be accepted for IVF technique as there are a very small number of sperm cells or severe sperm abnormalities are present. ICSI helps man and woman who do not want to use donor sperm, as it gives them a greater probability of success using the man's own sperm.

It is used to help couples where the man has had an irreversible vasectomy, or has no sperm in his semen due to missing tubes or blockages in his reproductive organs. This is useful for men with very low sperm counts. Sometimes it is possible to retrieve a few sperms from a man who has none recorded during semen analysis by taking a testicular biopsy under anaesthetic.

One sperm cell is injected straight into an egg in the clinic with the aid of a microscope and special instruments. Therefore, As a result the sperm does not have to swim to the egg or penetrate the outer layers of the egg. ICSI helps men who have problems with sperm motility or the sperms are unable to penetrate the outer coat of the egg for some unknown reason.

ICSI is actually an advanced IVF technique that increases the successful rate of pregnancy by increasing the number of eggs that are fertilised. Normal fertilization occurs in about 75-85% of eggs injected with sperm. (Advance Fertility Centre)




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